The 22-year-old Australian breezed past the 15-times Grand Slam champion in about one hour and 20 minutes.
Roger Federer returned from a month-long layoff with a 6-4, 6-4 second round victory over Roberto Bautista Agut on Tuesday at the Western and Southern Open in Cincinnati.
Former world number one Ana Ivanovic showed flashes of the form that took her to the pinnacle of tennis as she upset ninth seed Victoria Azarenka 2-6, 7-6, 6-2 in the first round of the Cincinnati Masters on Monday.
Russia's Vera Zvonareva rounded off a week of upsets with a 6-2, 6-4 victory over Katarina Srebotnik of Slovenia to win the Cincinnati Open on Sunday.
World No 1 Serena Williams fought her way to a 7-5, 7-5 win over defending champion Li Na to reach the final of the Western and Southern Open on Saturday and close in on one of the few titles to elude her.
Defending champion Serena Williams finished her last US Open tune-up in style by beating Romanian third seed Simona Halep 6-3, 7-6(5) to win the Western & Southern Open on Sunday.
Rafa Nadal continued his sizzling hardcourt form beating John Isner 7-6 (8), 7-6 (3) in the final of the Western and Southern Open on Sunday, setting up the Spaniard as the red-hot favourite heading into the U.S. Open.
Andrey Rublev made the most of Holger Rune's nerves to win a see-saw Monte Carlo final 5-7, 6-2, 7-5 on Sunday, as the Russian's talent was finally rewarded with a Masters title.
World number one Carlos Alcaraz faces a potential quarter-final clash with old foe Jannik Sinner in his US Open title defence, and American Coco Gauff is on a collision course with defending champion Iga Swiatek on the women's side.
Roger Federer survived an opening-match fright by outlasting Canada's Vasek Pospisil 7-6 (4), 5-7, 6-2 on Wednesday to claim his 300th Masters Series win and reach the third round of the Western and Southern Open in Cincinnati.
Defending champion Serena Williams reached the semi-finals of the Western & Southern tournament in Cincinnati but not before having her mettle tested in a 3-6, 6-4, 6-2 win over sixth-seeded Serb Ana Ivanovic on Friday.
Madison Keys stunned third seed Jessica Pegula 6-1, 6-3 in an all-American clash
Serena Williams brushed off some serving troubles before cruising to a 6-4, 6-3 win over Elina Svitolina on Saturday and will meet Simona Halep in the Western & Southern Open final.
The 43-year-old Bopanna and 35-year-old Ebden, who claimed two doubles titles on the ATP Tour earlier this year, will next face the unseeded British pair of Jacob Fearnley and Johannus Monday on Sunday.
The first teenager to play in a US Open final since Serena in 2001 there was symmetry to the moment as Gauff rallied to beat the second seeded Belarusian 2-6, 6-3, 6-2 and end a six-year barren stretch for American tennis fans, who were finally able to celebrate a homegrown champion.
India's Rohan Bopanna and his French partner Edouard Roger-Vasselin let go off five break-point chances as they lost to Marcel Granollers and Marc Lopez in the semi-final encounter of the ATP Cincinnati Masters.
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Former world number one Marat Safin was dumped out in the first round of the Cincinnati Masters on Monday, beaten 6-3 7-6 by German Nicolas Kiefer.
Coco Gauff became the first American to win a US Open singles title since Sloane Stephens in 2017.
Need to raise game against Djokovic, says Medvedev ahead of US Open final
Stanislas Wawrinka had to dig deep to beat Borna Coric at the Western & Southern Open in Cincinnati on Wednesday and conceded his thoughts had been far from tennis over the past few days.
Petra Kvitova overcame a sluggish start and 10 double faults to beat Madison Keys 6-7(6), 6-4, 6-3 on Saturday and advance to the final of the Cincinnati Open, where she will face Caroline Garcia, the first qualifier to reach the final of a WTA 1000 tournament.
Novak Djokovic enjoyed a stress-free return to US competition following a two year absence
Medvedev on everyone's US Open radar after first round rout
Bronny James, NBA legend LeBron James's 18-year-old son, suffered a cardiac arrest while practicing with the University of Southern California basketball team and was in stable condition.
Olympic champion Andy Murray restored some order at the Western & Southern Open by cutting down South African giant Kevin Anderson to reach the quarter-finals on an upset-filled Thursday in Cincinnati.
Fans are buzzing over the prospect of a rematch between world number one Alcaraz and second seed Djokovic in a potential New York finale
LeBron James thanked fans on Thursday for their love and prayers for his son Bronny, who suffered a cardiac arrest while training.
The confrontation comes days after the FBI executed a search warrant at former president Donald Trump's Florida estate.
Roger Federer avenged his Wimbledon final loss to Novak Djokovic by beating the top-seeded Serb 7-6(1), 6-3 on Sunday to capture his second consecutive Western & Southern Open title.
Photos from Day 5 action at the Western & Southern Open at Cincinnati on Thursday.
The governing body of women's tennis announced a new circuit structure on Tuesday with a "pathway to handing out equal prize money" for men and women at combined WTA 1000 and 500 events.
A crowd favourite for her creative playing style, Ons Jabeur rolls into her second straight Grand Slam championship match brimming with confidence, with lessons learned from her heartbreaking loss at the All England Club to Kazakhstan's Elena Rybakina.
Sinner is most likely to upset the applecart after the Italian's run to the Canadian Open title this month
The Maria Sharapova-Jimmy Connors partnership got off to a rocky start on Tuesday as Sloane Stephens shocked the third ranked Russian 2-6, 7-6(5), 6-3 at the Western and Southern Open.
Petra Kvitova added another happy memory at the All England Lawn Tennis Club
Rafael Nadal returns to the US Open for the first time in three years short of match practice and with big question marks about his fitness but few people will dismiss the Spaniard's chances of claiming a record-extending 23rd Grand Slam title.
Novak Djokovic has no intention of passing the torch to the next generation just yet.
IMAGES from all the action on Day 7 of the US Open played at the USTA Billie Jean King Tennis Center at Flushing Meadows in New York on Sunday.
Carlos Alcaraz ended Australian qualifier Max Purcell's dream run to reach the Cincinnati Open semi-finals
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